Massachusetts General HospitalHarvard Medical School

Clinical Care Research Education

Psychosis Clinical &
Research Program

At MGH PCRP, psychosis and schizophrenia are treated like other medical conditions—with compassion, specialized expertise, multidisciplinary care and innovation.

Members of the Psychosis Clinical and Research Program team together

24th annual · Registration open

Schizophrenia Education Day

Resilience in Schizophrenia

10 a.m.–2 p.m. ET · Boston

Free for patients, families, and friends.

About Us

The Massachusetts General Hospital Psychosis Clinical and Research Program (MGH PCRP), co-led by Drs. Oliver Freudenreich and Daphne Holt, seeks to improve quality of life for people with psychosis or schizophrenia by reducing distressing symptoms, improving function in school, work and relationships, and promoting better physical health.

Our team of clinicians and researchers conducts state-of-the-art research focused on medication intervention trials, neuroscience and brain imaging, genetics and psychosocial interventions. We offer comprehensive diagnostic evaluations, second-opinion consultations, a clozapine clinic and ongoing treatment for adolescent and adult patients with psychosis, including schizophrenia and related disorders.

Clinical Services

Five specialized services support people across different stages and treatment needs. Select a service to learn more or begin a referral.

The PCRP building at 151 Merrimac Street in Boston
Courtesy of Oliver Freudenreich

First-Episode and Early Psychosis Program (FEPP)

Coordinated evaluation, treatment and recovery support for adolescents and adults experiencing psychosis for the first time.

  • Ages 14–35
  • First episode of psychosis

Recovery and Ongoing Care Clinic (ROCC)

Ongoing psychiatric pharmacotherapy and group therapy for adults living with an established schizophrenia spectrum disorder.

  • Ages 18 and older
  • Established schizophrenia spectrum disorder

Psychosis Consultation Service

Patients and, when appropriate, family members meet with specialists for a one-time evaluation and recommendations. Recommendations are also communicated to the referring clinician.

  • All ages
  • Patients and families should ask their treating psychiatric provider to complete the referral form for the Psychosis Consultation Service

All referrals are screened for clinical appropriateness. Submitting a referral is not a guarantee of treatment. Patient and family consultation requests must be discussed with the current treating clinician.

Research at the PCRP

World-class researchers and caregivers work together to deepen our understanding of risk factors for psychosis, the full course of schizophrenia and related disorders, and to translate that understanding into compassionate, effective treatment. What makes our team unique is that many of our researchers are also clinicians who see patients.

Areas of Research

PCRP researchers and visitors inside the MGH Charlestown Navy Yard
Research LocationMGH Charlestown Navy Yard · 149 13th Street, Charlestown, MA 02129
  • Emotion and Social Neuroscience Lab (ESNL) ↗, directed by Dr. Daphne Holt, studies emotion and social cognition in psychosis and related conditions using behavioral, physiological and neuroimaging methods.
  • Resilience and Prevention Program (RAPP) ↗, directed by Dr. Daphne Holt, studies mechanisms of risk and resilience and evaluates practical interventions designed to strengthen resilience and reduce risk for mental health challenges.
  • Intervention Clinical Trials Program seeks better medication options for schizophrenia symptoms and the medical problems associated with existing medications.
  • Early Brain Development Initiative ↗, directed by Dr. Joshua Roffman, aims to discover and implement prenatal and early-life interventions that may prevent neuropsychiatric illness.
  • Sleep, Cognition and Neuropsychiatry Lab (SCAN) ↗, directed by Dr. Dara Manoach, investigates how sleep and circadian physiology influence cognition and psychiatric symptoms, including cognitive difficulties in schizophrenia.
  • Center of Excellence for Psychosocial and Systemic Research ↗, directed by Dr. Cori Cather, develops and evaluates psychosocial interventions, quality-improvement initiatives and community-informed approaches to mental health care.

Meet our team

PCRP Leadership

The PCRP leadership team includes expert clinicians and researchers who guide the program's clinical care, research and education.

Portrait of Abigail Donovan, MD

Abigail Donovan, MD

Director of Clinical Services, PCRP

Director, First-Episode and Early Psychosis Program

Medical Director, Acute Psychiatry Service

Assistant Professor of Psychiatry, Harvard Medical School

Portrait of Cori Cather, PhD

Cori Cather, PhD

Chief, Division of Public and Community Psychiatry

Director, Center of Excellence for Psychosocial and Systemic Research

Associate Professor of Psychology, Harvard Medical School

Making PCRP Possible

Program Operations

Leah and Marta support the coordination, development and day-to-day work of PCRP's clinical, research, and educational programs.

Portrait of Leah Namey, MPH

Leah Namey, MPH

Senior Program Manager, PCRP

Portrait of Marta Hernandez

Marta Hernandez

Administrative Coordinator, PCRP

Meet the full PCRP team

Alexandra Volpacchio, PsyD

Baktash Babadi, MD, PhD

Bryan Baxter, PhD

Carol Lim, MD, MPH

Cheryl Foo, PhD

Dara Manoach, PhD

Dimitrios Mylonas, PhD

Drew Coman, PhD

A. Eden Evins, MD, MPH

Elaine Shen, MD

Faith Scanlon, PhD

Gina Kuperberg, MD, PhD

Hamdi Eryilmaz, PhD

Hassan Ramadan

John Tyson, MD

Kelly Irwin, MD

Lauren Utter, PsyD

Louis Vinke, PhD

Merranda McLaughlin, PhD

Sarah MacLaurin, PMHNP

Shreedhar Paudel, MD, MPH

Temitope Ogundare, MD

Thomas D'Amario

Victoria Hasler, PhD

Patient & Family Resources

Schizophrenia and psychosis are serious, but also misunderstood, conditions. If you think a loved one is dealing with psychosis, it is vital to get help in the early stages of illness. Begin by learning more about schizophrenia and other forms of psychosis.

View our resources ›

Support Our Work

Families are our highest priority. We partner with patients to provide high-quality specialty care tailored to each family’s preferences and needs. Your support helps us expand care, education and research.

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